I don't know first hand what you might achieve by chipping your truck but I'm skeptical of claims that performance chips improve fuel economy much. The manufacturers spend tons of time and money tuning for best economy to start with so they get the best numbers possible in the EPA tests to meet the Federal CAFE standards. I highly doubt that some little aftermarket company could do something the manufacturers weren't able to do. If you were looking for more performance that might be a different story.
If you really want to go the chip route I'm sure there are lots of forums for the 5.7 Hemi. I looked at the Toyota Highlander ones one time and was quickly convinced the chips were a gimmick. By increasing ignition timing they can possibly reduce fuel consumption but at the expense of running high octane fuel so its probably a losing trade off.
if you bought your truck for towing a larger trailer you might have pretty short gearing at cruise speeds so you might consider changing to a taller final drive ratio which would reduce engine rpm and pumping losses as long as the tranny didn't decide to drop down a gear to compensate.
I still only get 13.5-15 mpg towing my pod at 60-65 with my Highlander on 87 octane. Our fuel economy is ultimately limited at freeway speeds by the pod drag coefficient no matter what your TV is. So the easiest way to boost efficiency (after going to the max allowable tire pressure to reduce rolling resistance) is to slow down as much as is safe and you can stand. The hp required to overcome drag at 65 mph is 27% higher than at 60. That results in about 1.3 mpg reduction in fuel economy if 2/3 of your total load is drag and 1/3 is rolling resistance, which is about right.
You can also try one of the aftermarket aerodynamic spoilers and see if that helps. Some folks on this forum seem to have had an improvement doing that.